期刊
VIROLOGY
卷 304, 期 2, 页码 379-391出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/viro.2002.1658
关键词
infectious salmon anemia virus; ISAV; ISA; hemagglutinin; HA; polymorphism
类别
Infectious salmon anemia (ISA) is an emerging disease in farmed Atlantic salmon with important commercial consequences. The pathogenicity of the ISA virus (ISAV; an orthomyxovirus) varies, observed as differences in disease development and clinical signs. A small polymorphic region (PR) in the ISAV genomic segment encoding the hemagglutinin (HA) has been described. An analysis of 33 HA gene sequences from historical and recent ISA outbreaks was performed, added to a selection of previously published HA sequences. A differential deletion model explaining the generation of HA polymorphism is proposed. The European ISAV sequences could be grouped according to deletion patterns in PR. Cell-culture replication and cytopathic effect varied between viruses from different PR groups. A rather complex epidemiology is suggested, as (a) HA sequences representing several PR variants were detected in three samples; (b) identical mutations occurred indifferent genetic lineages; and (c) large genetic differences were present in closely related viruses. (C) 2002 Elsevier Science (USA).
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