期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 510, 期 1-2, 页码 131-140出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0027-5107(02)00258-0
关键词
transcriptional mutagenesis; DNA lesions
资金
- NCI NIH HHS [CA73041, CA78622] Funding Source: Medline
The genes of all organisms are continuously damaged by extrinsic and intrinsic physical and chemical agents. If the resulting DNA damage is left unrepaired, a number of deleterious biological consequences may result including the production of mutant proteins which can change the cellular phenotype. The majority of DNA damage-induced mutagenesis studies are based on models of DNA polymerase errors occurring in the vicinity of the lesion. In contrast, few studies have addressed the possibility that mutagenesis at the level of transcription (i.e. when RNA polymerase bypasses a lesion and a misincorporation event occurs) may also be an important source of mutant proteins, particularly in nondividing cell populations. This article reviews a number of recent studies on translesion synthesis by RNA polymerases resulting in the production of mutant transcripts (transcriptional mutagenesis). Over a dozen different types of DNA damage are now known to be bypassed with various degrees of efficiency and miscoding abilities by the transcriptional elongation machinery. Some important biological implications of transcriptional mutagenesis are discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
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