期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 510, 期 1-2, 页码 107-120出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0027-5107(02)00256-7
关键词
repair; recombination; replication
资金
- NIGMS NIH HHS [GM32335, GM52725] Funding Source: Medline
When replication forks stall or collapse at sites of DNA damage, there are two avenues for fork rescue. Mutagenic translesion synthesis by a special class of DNA polymerases can move a fork past the damage, but can leave behind mutations. The alternative nonmutagenic pathways for fork repair involve cellular recombination systems. In bacteria, nonmutagenic repair of replication forks may occur as often as once per cell per generation, and is the favored path for fork restoration under normal growth conditions. Replication fork repair is almost certainly the major function of bacterial recombination systems, and was probably the impetus for the evolution of recombination systems. Increasingly, the nonmutagenic repair of replication forks is seen as a major function of eukaryotic recombination systems as well. (C) 2002 Elsevier Science B.V. All rights reserved.
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