期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 198, 期 1-2, 页码 115-121出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0303-7207(02)00407-0
关键词
prostate (rat prostate); TRAIL (tumor necrosis factor-alpha-related apoptosis-inducing ligand); TNF-alpha
Tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor-alpha (TNF-alpha) family of cytokines that is known to induce apoptosis upon binding to its death domain-containing receptors, DR4/TRAIL-R1 and DR5/TRAIL-R2. Two additional TRAIL receptors, DcR1/TRAIL-R3 and DcR2/TRAIL-R4, lack functional death domains and act as decoy receptors for TRAIL. In this study, the presence of TRAIL and its receptors was investigated in adult rat hormonosensitive ventral prostate. TRAIL and its receptors were identified in the rat ventral prostate in terms of protein and mRNA. TRAIL and its receptors were immunolocalized in prostatic epithelial cells. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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