期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1585, 期 2-3, 页码 114-125出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1388-1981(02)00331-1
关键词
ceramide; apoptosis; topology; metabolism; analysis; mass spectrometry; binding effector; ceramide-activated protein phosphatase
Recent years have witnessed significant advances in the understanding of the role of ceramide in apoptosis. This review summarizes these recent findings and discusses insights from studies of ceramide metabolism, topology, and effector actions. The recent identification of several genes for enzymes of ceramide metabolism, the development of mass spectrometric methods for ceramide analysis, and the increasing molecular and pharmacological tools to probe ceramide metabolism and function promise an accelerated phase in defining the molecular and biochemical details of the role of ceramide in apoptosis. (C) 2002 Elsevier Science B.V All rights reserved.
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