期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 1, 页码 51-55出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00855-7
关键词
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Acetylpyridine benzoyl hydrazone (APBH) 1 and its copper complex [{(APBH)CuCl}(2)].(EtOH) 2 were structurally characterized by elemental analysis, magnetic measurements, spectroscopy, electrochemistry and single crystal X-ray diffraction studies. The ligand assumes Z-isomeric form and planar geometry in solid state, coordinating through pyridyl nitrogen, azomethine nitrogen and the carbonyl oxygen of the benzoyl group. The copper complex is dimeric and has a distorted octahedral geometry in which the two copper atoms are bridged by two chloride atoms. Antimycobacterial screening of ligand and its copper compound against Mycobacterium smegmatis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2002 Elsevier Science Ltd. All rights reserved.
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