期刊
CANCER LETTERS
卷 189, 期 1, 页码 49-57出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(02)00502-5
关键词
melatonin; MT1 receptor; breast cancer; athymic nude mice
类别
资金
- NCI NIH HHS [2R01CA-54152-10] Funding Source: Medline
Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells significantly enhances the response of these cells to the growth-inhibitory actions of melatonin. Athymic nude mice implanted with MT1-overexpressing MCF-7 cells developed significantly fewer palpable tumors (60% reduction) compared to mice receiving vector-transfected MCF-7 cells (vt-MCF-7). In response to exogenous melatonin, tumor incidence in the mice receiving the MT1-overexpressing MCF-7 cells was decreased by 80% compared to mice receiving vt-MCF-7 cells. Interestingly, daily melatonin administration did not decrease tumor incidence in mice receiving vt-MCF-7 cells, but rather stimulated overall tumor formation. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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