期刊
SCIENCE
卷 299, 期 5604, 页码 247-251出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1079477
关键词
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资金
- NIBIB NIH HHS [R21 EB002473, R21 EB002473-02] Funding Source: Medline
Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76 deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals.
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