Synthesis and 1,3-dipolar cycloadditions of a new enantiopure cyclic nitrone

A new enantiopure cyclic nitrone has been efficiently synthesized from a D-glyceraldehyde derivative. It's 1,3-dipolar cycloaddition to different classes of dipolarophiles show complete antifacial selectivity, furnishing highly functionalized enantiopure bicyclic isoxazolidines. (C) 2002 Elsevier Science Ltd. All rights reserved.