Solid-phase synthesis of unsymmetrical ureas through the use of Kenner safety-catch linker

A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution. (C) 2003 Elsevier Science Ltd. All rights reserved.