期刊
NEURON
卷 37, 期 2, 页码 263-274出版社
CELL PRESS
DOI: 10.1016/S0896-6273(02)01168-6
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资金
- NIDA NIH HHS [DA 00266] Funding Source: Medline
- NIMH NIH HHS [MH 61873] Funding Source: Medline
The morphogenesis of dendritic spines, the major sites of excitatory synaptic transmission in the brain, is important in synaptic development and plasticity. We have identified an ephrinB-EphB receptor trans-synaptic signaling pathway which regulates the morphogenesis and maturation of dendritic spines in hippocampal neurons. Activation of the EphB receptor induces translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector PAK. Overexpression of dominant-negative EphB receptor, catalytically inactive kalirin, or dominant-negative Rac1, or inhibition of PAK eliminates ephrin-induced spine development. This novel signal transduction pathway may be critical for the regulation of the actin cytoskeleton controlling spine morphogenesis during development and plasticity.
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