期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 278, 期 4, 页码 2758-2766出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M209572200
关键词
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NF-kappaB represents a family of eukaryotic transcription factors participating in the regulation of various cellular genes involved in the immediate early processes of immune, acute-phase, and inflammatory responses. Cellular localization and consequently the transcriptional activity of NF-kappaB is tightly regulated by its partner IkappaBalpha. Here, we show that the p65 subunit of NF-kappaB is acetylated by both p300 and PCAF on lysines 122 and 123. Both HDAC2 and HDAC3 interact with p65, although only HDAC3 was able to deacetylate p65. Acetylation of p65 reduces its ability to bind kappaB-DNA. Finally, acetylation of p65 facilitated its removal from DNA and consequently its IkappaBalpha-mediated export from the nucleus. We propose that acetylation of p65 plays a key role in IkappaBalpha-mediated attenuation of NF-kappaB transcriptional activity which is an important process that restores the latent state in post-induced cells.
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