期刊
FEMS MICROBIOLOGY LETTERS
卷 218, 期 2, 页码 223-230出版社
OXFORD UNIV PRESS
DOI: 10.1016/S0378-1097(02)01148-5
关键词
ansamycin; antitumor; biosynthesis; cancer chemotherapy; Hsp90; polyketide synthase
类别
资金
- NCI NIH HHS [R43 CA96262] Funding Source: Medline
- PHS HHS [AL38947] Funding Source: Medline
We illustrate the use of a PCR-based method by which the genomic DNA of a microorganism can be rapidly queried for the presence of type I modular polyketide synthase genes to clone and characterize, by sequence analysis and gene disruption, a major portion of the geldanamycin production gene cluster from Streptomyces hygroscopicus var. geldanus NRRL 3602. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据