期刊
CANCER LETTERS
卷 189, 期 2, 页码 117-128出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(02)00510-4
关键词
Ras; Rho; Rac; Cdc42; Ral; epithelial cells; fibroblasts; tumorigenesis; cell migration; basement membrane
类别
With over 100 members in humans, the Ras superfamily is a diverse group of monomeric G proteins participating in many cellular processes. Members of the Ras, Rho, and Arf families have been shown to regulate cell motility in fibroblasts and epithelial cells. Ras and Rho family members are also widely involved in human tumorigenesis, either through activating mutations or by overexpression. In this review, tools for studying carcinoma cell migration are discussed and evidence for regulation of carcinoma cell motility by specific Ras superfamily members is summarized. Novel emerging mechanisms of migration in carcinoma cells involving RhoC and Ral are also discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据