期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 94, 期 2, 页码 485-489出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00823.2002
关键词
Poiseuille; shear rate; whole blood viscosity
Shear stress (SS) is thought to be constant throughout the vascular system. Evidence for this supposition is scarce, however. To verify this hypothesis in vivo, we assessed common carotid (CCA) and brachial artery (BA) peak and mean wall shear rate (SR) noninvasively in 10 healthy volunteers (23.7 +/- 3.4 yr) with an ultrasound SR estimation system. SS was estimated from SR and calculated whole blood viscosity. SR was higher (P < 0.05) in the CCA (mean: 359 ± 111 s(-1); peak: 1,047 ± 345 s(-1)) than in the BA (mean: 95 ± 24 s(-1); peak: 770 ± 170 s(-1)). Whole blood viscosity was higher in the BA than in the CCA (5.1 ± 0.7 vs. 3.3 ± 0.6 mPa.s; P < 0.001). Peak SS did not differ between the CCA and the BA, whereas mean SS was significantly higher in the CCA (1.15 +/- 0.21 Pa) than in the BA (0.48 +/- 0.15 Pa; P < 0.001). These results demonstrate that BA SS strongly deviates from CCA SS in vivo.
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