期刊
BIOPOLYMERS
卷 68, 期 2, 页码 234-249出版社
WILEY
DOI: 10.1002/bip.10221
关键词
ribosomes; assembly; 30S subunit; in vitro reconstitution
资金
- NIGMS NIH HHS [R01 GM062432] Funding Source: Medline
Ribosomes are large macromolecular complexes responsible for cellular protein synthesis. The smallest known cytoplasmic ribosome is found in prokaryotic cells; these ribosomes are about 2.5 MDa and contain more than 4000 nucleotides of RNA and greater than 50 proteins. These components are distributed into two asymmetric subunits. Recent advances in structural studies of ribosomes and ribosomal subunits have revealed intimate details of the interactions within fully assembled particles. In contrast, many details of how these massive ribonucleoprotein complexes assemble remain elusive. The goal of this review is to discuss some crucial aspects of 30S ribosomal subunit assembly. (C) 2003 Wiley Periodicals, Inc.
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