期刊
ANDROLOGIA
卷 35, 期 1, 页码 55-63出版社
BLACKWELL VERLAG GMBH
DOI: 10.1046/j.1439-0272.2003.00537.x
关键词
cytokines; inflammatory disease; lipopolysaccharide; LPS; male accessory gland infections; spermatogenesis; steroidogenesis
类别
资金
- NICHD NIH HHS [HD27516] Funding Source: Medline
Inflammatory disease is known to affect male reproductive function and fertility. Male accessory gland infections (MAGI) account for almost 15% of all cases of male infertility seen in infertility clinics. Infections of the male accessory glands are associated with increased counts of white blood cells in semen and elevated levels of pro-inflammatory cytokines in the semen and the testis. Numerous studies have underscored the importance of cytokines in the regulation of testicular and glandular function during pathophysiological events as well as under normal physiological conditions when cytokines act as growth and differentiation factors. The purpose of this paper is to particularly review the role of cytokines in the regulation of Leydig cell function in the testis primarily under pathophysiological conditions, and also considers clinical investigations that help to improve the evaluation and treatment of male infertility.
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