期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 120, 期 3, 页码 484-487出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04113.x
关键词
adult ALL; E2A-PBX1; t(1;19) translocation; FISH
类别
Molecular and cytogenetic studies performed in 305 adult acute lymphoblastic leukaemia (ALL) patients enrolled in the gimema (Gruppo Italiano Malattie EMatologiche dell'Adulto) multicentric protocols identified an E2A-PBX1 fusion and/or t(1;19) in 10 patients (3.3%). All had common ALL, were mostly CyIg(+) and were CD34/CD13/CD33(-) . Nine patients achieved a complete remission (CR); five patients showed a haematological relapse after 7 months (median). Four patients are alive in first CR with a median follow-up of 29 months; three patients are molecularly negative. This abnormality is frequently associated with early treatment failure. E2A-PBX1 (+) adult ALL should be considered for intensified treatment strategies and monitoring of minimal residual disease.
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