期刊
ASTROBIOLOGY
卷 13, 期 1, 页码 1-17出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ast.2012.0876
关键词
2-D clinostat; 3-D clinostat; Gravity; Magnetic levitation; Random positioning machine; Simulated microgravity; Space biology
资金
- ESA [4200022650]
- Spanish Space Program in the Plan Nacional de Investigacion Cientifica y Desarrollo Tecnologico'' [AYA2009-07792-E, AYA2009-07952, AYA2010-11834-E]
- German Space Administration grants on behalf of Bundesministerium fur Wirtschaft und Technologie [50WB0527, 50WB0815, 50WB0828, 50WB0921]
- Dutch Space Research Organization NWO-ALW-SRON grant [MG-057]
- EuroMagNET II under the EU [228043]
- Stichting voor Fundamenteel Onderzoek der Materie (FOM)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
- UK Engineering and Physical Sciences Research Council (EPSRC) [GR/S83005/01, EP/G037647/1]
- EPSRC [EP/I004599/1]
- C-DIP grant [EP/J005452/1]
- Engineering and Physical Sciences Research Council [GR/S83005/01, EP/I004599/1, EP/J005452/1, EP/G037647/1] Funding Source: researchfish
- Science and Technology Facilities Council [ST/J001384/1, ST/G002355/1, PP/F000057/1, PP/D000955/1, ST/J000035/1] Funding Source: researchfish
- EPSRC [EP/G037647/1, EP/J005452/1] Funding Source: UKRI
- STFC [PP/D000955/1, ST/J000035/1, PP/F000057/1, ST/G002355/1, ST/J001384/1] Funding Source: UKRI
Research in microgravity is indispensable to disclose the impact of gravity on biological processes and organisms. However, research in the near-Earth orbit is severely constrained by the limited number of flight opportunities. Ground-based simulators of microgravity are valuable tools for preparing spaceflight experiments, but they also facilitate stand-alone studies and thus provide additional and cost-efficient platforms for gravitational research. The various microgravity simulators that are frequently used by gravitational biologists are based on different physical principles. This comparative study gives an overview of the most frequently used microgravity simulators and demonstrates their individual capacities and limitations. The range of applicability of the various ground-based microgravity simulators for biological specimens was carefully evaluated by using organisms that have been studied extensively under the conditions of real microgravity in space. In addition, current heterogeneous terminology is discussed critically, and recommendations are given for appropriate selection of adequate simulators and consistent use of nomenclature.
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