期刊
BIOSYSTEMS
卷 68, 期 2-3, 页码 171-185出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0303-2647(02)00094-1
关键词
intracellular signalling pathways; autonomous agents; blackboard architecture; virtual laboratory
The theory of behaviour-based systems (or autonomous agents) constitutes a useful approach for the modelling of intracellular signalling networks. In this sense, a cell can be seen as an adaptive autonomous agent or as a society of such agents, where each can exhibit a particular behaviour depending on its cognitive capabilities. We present an intracellular signalling model obtained by integrating several computational techniques into an agent-based paradigm. Cellulat, the model, takes into account two essential aspects of the intracellular signalling networks: (1) cognitive capacities, which are modelled as the agent abilities to interact with the surrounding medium and (2) a spatial organisation, this last obtained using a shared data structure through which the agents communicate between them. We propose a methodology for the modelling of intracellular signalling pathway using Cellulat and we discuss the goal of a virtual laboratory based on our model and presently under development. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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