期刊
JOURNAL OF CHROMATOGRAPHY A
卷 988, 期 1, 页码 127-133出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(02)02022-8
关键词
mass spectrometry; organic acids
A capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) method was developed to facilitate identification and determination of eleven low-molecular-mass (LMW) organic acids (i.e. oxalic, lactic, malonic, maleic, citric, tartaric, adipic, glutaric, gluconic, isosaccharinic and succinic acid) in different sample matrices. This CZE method was adapted to suit MS conditions. Sheath liquid, sheath flow and MS parameters were optimized to achieve high mass spectrometric sensitivity. The CZE-ESI-MS procedure showed good sensitivity (limit of detection of <0.05-0.7 mg/l for all acids), linearity (r(2) =0.9925-0.9998) and reproducibility (2.09-5.34% RSD). The applicability of the CZE-ESI-MS was demonstrated on LMW organic acids in an ale sample. In addition the (here presented) method also provided quantification of fumaric, galacturonic and 2-ketoglutaric acid with high sensitivity. (C) 2002 Elsevier Science B.V. All rights reserved.
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