期刊
JOURNAL OF BIOLOGICAL RHYTHMS
卷 18, 期 1, 页码 12-25出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730402239673
关键词
Drosophila; sleep-like rest; gender dimorphism; steep regulation; longevity; BMAL1
资金
- NHLBI NIH HHS [R01HL59496] Funding Source: Medline
- NIA NIH HHS [P01 AG-17628] Funding Source: Medline
- NINDS NIH HHS [R01NS35703] Funding Source: Medline
The central clock is generally thought to provide timing information for rest/activity but not to otherwise participate in regulation of these states. To test the hypothesis that genes that are components of the molecular clock also regulate rest, the authors quantified the duration and intensity of consolidated rest and activity for the four viable Drosophila mutations of the central clock that lead to arrhythmic locomotor behavior and for the pdf mutant that lacks pigment-dispersing factor, an output neuropeptide. Only the cycle (cyc(01)) and Clock (Clk(lrk)) mutants had abnormalities that mapped to the mutant locus, namely, decreased consolidated rest and grossly extended periods of activity. All mutants with the exception of the cyc(01) fly exhibited a qualitatively normal compensatory rebound after rest deprivation. This abnormal response in cyc(01) was sexually dimorphic, being reduced or absent in males and exaggerated in females. Finally, the cyc(01) mutation shortened the life span of male flies. These data indicate that cycle regulates rest and life span in male Drosophila.
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