期刊
CURRENT OPINION IN MICROBIOLOGY
卷 6, 期 1, 页码 43-49出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S1369-5274(03)00004-3
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Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells. They have emerged as a paradigm of a bacterial toolbox allowing recognition of different host receptors and orchestrating the cell type tropism displayed by pathogenic Neisseriae. Recent work has highlighted the molecular basis of Opa-protein-host-receptor interaction and has shed new light on the functional consequences of this interaction with regard to bacterial attachment, invasion, and responses elicited in particular host cells.
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