期刊
SYNLETT
卷 -, 期 2, 页码 271-273出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-36782
关键词
marine alkaloid; metathesis; silyloxypyrrole alkylation; tetramate reduction; 1-azaspiro[4.5]decane
A stereoselective synthesis of the tricyclic core in racemic form of the marine alkaloid Lepadiformine is described from 4-methoxy-3-pyrrolin-2-one (methyl tetramate). Key steps involve 5,5-dialkylation of the tetramate, metathesis closure to an A/C 1-azaspirocycle and stereoselective hydrogenation for the trans A/B 1-azadecalin system.
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