期刊
EXPERIMENTAL EYE RESEARCH
卷 76, 期 2, 页码 145-153出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S0014-4835(02)00278-6
关键词
alpha-crystallin; small heat-shock proteins; chaperones; aggregation; cataract
资金
- NEI NIH HHS [R-37 EY3897] Funding Source: Medline
Alpha A and alpha B-crystallins are a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family they possess chaperone-like function. The alpha-crystallins and especially alpha B is also found outside the lens having an extensive tissue distribution. Alpha B-crystallin is found to be over-expressed in many neurological diseases, and mutations in alpha A or B-crystallin can cause cataract and myopathy. This review deals with some of the unique properties of the alpha-crystallins emphasizing especially what we don't know about its function and structure. (C) 2003 Elsevier Science Ltd. All rights reserved.
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