期刊
NATURE IMMUNOLOGY
卷 4, 期 2, 页码 117-123出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni882
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- NIAID NIH HHS [1R01 AI48674-01, R01 AI056156, R01 AI048674] Funding Source: Medline
The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.
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