4.3 Article

Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats

期刊

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
卷 87, 期 2, 页码 1389-1395

出版社

ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765201520140638

关键词

Acetylcholinesterase; Amphetamine; Dopamine; Fenproporex

资金

  1. Programa de Pos-Graduacao em Ciencias da Saude - Universidade do Extremo Sul Catarinense (UNESC)
  2. Nucleo de Excelencia em Neurociencias Aplicadas de Santa Catarina (NENASC)
  3. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  4. Instituto Nacional de Ciencia e Tecnologia Translacional em Medicina (INCT)

向作者/读者索取更多资源

Fenproporex is the second most commonly amphetamine-based anorectic consumed worldwide; this drug is rapidly converted into amphetamine, in vivo, and acts by increasing dopamine levels in the synaptic cleft. Considering that fenproporex effects on the central nervous system are still poorly known and that acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine, the present study investigated the effects of acute administration of fenproporex on acetylcholinesterase activity in brain of young rats. Young male Wistar rats received a single injection of fenproporex (6.25, 12.5 or 25mg/kg i.p.) or vehicle (2% Tween 80). Two hours after the injection, the rats were killed by decapitation and the brain was removed for evaluation of acetylcholinesterase activity. Results showed that fenproporex administration increased acetylcholinesterase activity in the hippocampus and posterior cortex, whereas in the prefrontal cortex, striatum and cerebellum the enzyme activity was not altered. In conclusion, in the present study we demonstrated that acute administration of fenproporex exerts an effect in the cholinergic system causing an increase in the activity of acetylcholinesterase in a dose-dependent manner in the hippocampus and posterior cortex. Thus, we suggest that the imbalance in cholinergic homeostasis could be considered as an important pathophysiological mechanism underlying the brain damage observed in patients who use amphetamines such as fenproporex.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据