期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 71, 期 3, 页码 315-325出版社
WILEY-LISS
DOI: 10.1002/jnr.10501
关键词
PPAR-gamma; 15d-PGJ(2); microglia; EAE; brain abscess
资金
- NIMH NIH HHS [MH-65297] Funding Source: Medline
- NINDS NIH HHS [R01 NS042860, NS-40730, R01 NS042860-01A1] Funding Source: Medline
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in glucose and lipid metabolism. More recently, PPAR-gamma ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR-gamma agonists have been demonstrated to have similar effects on microglia. PPAR-gamma agonists also ameliorate experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This Mini-Review summarizes the effects of PPAR-gamma agonists in mediating immune responses and the potential of these agonists in the treatment of inflammatory disorders of the CNS. (C) 2002 Wiley-Liss, Inc.
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