期刊
AVIAN PATHOLOGY
卷 32, 期 1, 页码 81-93出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/0307945021000070750
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Four serial passages of six Newcastle disease virus (NDV) isolates were performed in two-week-old White Leghorns. The viruses were recovered from chickens (Ckn-Live Bird Market and Ckn-Australia isolates), exotic (Yellow Nape [YN] Parrot, Pheasant, and Dove isolates) and wild birds (Anhinga isolate). Infected chickens were monitored clinically and humanely killed to sample tissues for histopathology and immunohistochemistry. Pathogenicity tests, to assess the virulence of the isolates for chickens, and sequence analysis of the fusion protein cleavage site were performed before and after passages. The moderately virulent Dove isolate became highly virulent with serial passage. The originally highly virulent Pheasant isolate had an increase in the intracerebral pathogenicity index (ICPI) and the intravenous pathogenicity index (IVPI) with passages in chickens. Virulence increase was not observed with Ckn-LBM, YN Parrot, Ckn-Australia, or Anhinga isolates after four chicken passages. The results demonstrate the high risk for domestic chickens represented by some NDV-infected non-poultry species, such as doves.
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