期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 2, 期 4, 页码 166-170出版社
SPRINGER-VERLAG
DOI: 10.1007/s102380300001
关键词
endothelins; endothelin-1; jogging; cycling; plasma
Endothelin-1 plays an important role as a paracrine factor in the regulation of regional blood flow. Plasma levels may represent the net result of spill-over from local stimulation/release and elimination of endothelin-1. In order to compare changes in the concentration of endothelin-1 in the plasma of subjects performing different types of sports exercises we measured immunoreactive endothelin-1 in healthy volunteers (n=20) performing in random order jogging on a treadmill and cycling on a bicycle ergometer, for 30 min each. Plasma immunoreactive endothelin-1 increased significantly after jogging (2.13 +/- 0.8 pg/ml versus 2.6 +/- 0.8 pg/ml, before and after exercise, respectively, P<0.03), whereas it decreased after cycling (2.45 +/- 0.76 pg/ml versus 2.25 +/- 0.9 pg/ml, before and after exercise, respectively, P<0.03). We suggest that microtraumatizing effects on the endothelial lining are more pronounced during jogging than during cycling, resulting in a greater increase in plasma endothelin-1, which is too high to be immediately eliminated by the lung despite exercise-induced enhanced pulmonary perfusion. In contrast, similarly enhanced lung perfusion together with a relatively lower stimulation of endothelin-1 compared with jogging, may explain the net decrease in plasma after cycling.
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