期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 7, 期 1, 页码 91-96出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(02)00002-9
关键词
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Forward chemical genetics is a new method to systematize the discovery and use of small molecules as tools for basic biological research. This approach requires three basic components: a library of compounds; an assay, in which the library is screened for a cellular or organismal phenotype; and a method to trace an active compound to its biological target. Bioactive compounds have traditionally been isolated from natural product extracts, although 'diversity-oriented synthesis' and commercial compound collections are gaining in prominence. New techniques, such as image-based screening and the cytoblot method, have increased the throughput of phenotypic assays. Strategies are also being developed to streamline target identification using molecular biological approaches.
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