期刊
JOURNAL OF BACTERIOLOGY
卷 185, 期 4, 页码 1459-1461出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.185.4.1459-1461.2003
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2-Aminopurine treatment of Escherichia coli induces a reversible phenotype of DNA mismatch repair deficiency. This transient phenotype results in a 300-fold increase in the frequency of interspecies conjugational recombination with a Salmonella enterica serovar Typhimurium Hfr donor. This method can be used for the generation of biodiversity by allowing recombination between diverged genes and genomes.
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