期刊
CLINICAL RADIOLOGY
卷 58, 期 2, 页码 148-153出版社
W B SAUNDERS CO LTD
DOI: 10.1053/crad.2002.1080
关键词
Creutzfeldt-Jakob; variant CJD; sporadic CJD; magnetic resonance spectroscopy; N-acetylaspartate
AIM: To study the proton MR spectroscopic findings in Creutzfeldt-Jakob disease (CJD) (sporadic and variant). MATERIALS AND METHODS: MR imaging and proton MR spectra were acquired in two patients with sporadic CJD (biopsy proven) and one patient with variant CJD. RESULTS: The two patients with sporadic CJD demonstrated MR signal change within the basal ganglia and thalami and reduced N-acetylaspartate (NAA):creatine ratios. The patient with variant CJD showed characteristic signal change within the pulvinar of the thalami and a markedly reduced N-acetylaspartate:creatine ratio. CONCLUSION: All three patients with CJD demonstrated evidence of reduced N-acetylaspartate: creatine ratios on MR spectroscopy. These changes imply that neuronal loss and/or dysfunction is a consistent finding in established (C) 2003 The Royal College of Radiologists. Published by Elsevier Science Ltd. All rights reserved.
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