期刊
JOURNAL OF NATURAL PRODUCTS
卷 66, 期 2, 页码 247-250出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0204601
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资金
- NCI NIH HHS [CA 67775] Funding Source: Medline
The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.
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