期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 47, 期 2, 页码 755-758出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.2.755-758.2003
关键词
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A Klebsiella pneumoniae isolate was identified that had reduced susceptibility to several expanded-spectrum cephalosporins and imipenem. That isolate produced a chromosome-encoded SHV-type beta-lactamase, SHV-38, that had an alanine to valine substitution in position Ambler 146 compared to beta-lactamase SHV-1. The kinetic parameters for purified beta-lactamases SHV-38 and SHV-1 showed that the hydrolytic spectrum of SHV-38 included only ceftazidime and imipenem. This report is the first example of an SHV-type beta-lactamase capable of hydrolyzing imipenem.
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