期刊
TRENDS IN IMMUNOLOGY
卷 24, 期 2, 页码 55-58出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(02)00031-5
关键词
-
类别
The polymeric Ig receptor (plgR) ensures efficient secretion of polymeric IgA (plgA) at mucosal surfaces. On basal to apical transport across epithelial cells, the pIgR extracellular domain is cleaved, releasing secretory component (SC) in association with plgA. This finds its raison d'etre in the recent observation that SC is directly involved in the protective function of secretory IgA. In addition, free SC exhibits scavenger properties with respect to enteric pathogens. However, although plgR dedicates its life to mucosal protection, it also seems to permit pathogen entrance through the epithelial barrier. The multiple mechanisms that they are involved in make pIgR and SC instrumental to mucosal immunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据