期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 16, 期 2, 页码 158-162出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0895-7061(02)03245-4
关键词
hypertension; genetics; linkage
资金
- NHLBI NIH HHS [U01 HL54527-0151] Funding Source: Medline
Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at similar to10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. (C) 2003 American Journal of Hypertension, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据