期刊
JOURNAL OF NATURAL PRODUCTS
卷 66, 期 2, 页码 272-275出版社
AMER CHEMICAL SOC
DOI: 10.1021/np020315n
关键词
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Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (H-1, C-13, COSY, H-1 detected direct, and long-range C-13-H-1 correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity.
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