期刊
OSTEOARTHRITIS AND CARTILAGE
卷 11, 期 2, 页码 133-140出版社
W B SAUNDERS CO LTD
DOI: 10.1053/joca.2002.0871
关键词
osteoarthritis; pannus-like tissue; MMP3; IL-1 beta
Objective: To investigate and characterize pannus-like tissue which is often present on osteoarthritic articular cartilage. Design: Cartilage specimens from 15 knee and five hip joints of patients with osteoarthritis (OA) undergoing arthroplasty were stained for HE and Safranin-O. They were also immunostained by antitype I collagen, type II collagen, CD68, IL-1beta and MMP3 antibodies. Results: Ninety percent of joints have pannus-like tissue on the articular surface, preferentially in a marginal area. The articular cartilage was divided into three regions according to the location: the marginal zone, the intermediate zone and the paraeburnated zone. Pannus-like tissue in OA knee joint occurred 45.9%, 27.5% and 11.1% of the surface of each region respectively. Histologically, pannus-like tissue could be classified into the vascular type and the fibrous type. Extracellular matrix of both types of tissues were negative for Safranin-O and type II collagen, but positive for type I collagen. IL-1beta and MMP3 expressing cells are predominant in pannus-like tissue, whereas CD68 positive cells were infiltrated in only a few samples. Vascular type tissue kept continuity with bone marrow suggesting mesenchymal origin. Conclusion: Pannus-like tissue exists in advanced CA cartilage, preferentially in the marginal zone. It expressed IL-1beta and MMP3, which strongly suggests that it contributes to cartilage degradation. (C),2003 Published by Elsevier Science Ltd on behalf of OsteoArthritis Research Society International.
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