期刊
PHARMACEUTICAL BIOLOGY
卷 41, 期 1, 页码 68-71出版社
TAYLOR & FRANCIS LTD
DOI: 10.1076/phbi.41.1.68.14697
关键词
ginger; country-made liquor; lipid peroxidation; alcoholic liver disease
The effect of an ethanol extract of ginger was studied on country-made liquor (CML)-induced liver injury in rats. Hepatotoxicity was induced by administering CML (3 ml/100 g/day in 2 divided doses) and corn oil (1 ml/100 g/day, in a single dose) orally for 21 days. The administration of ginger ethanolic extract (200 mg/kg) orally from day 15 to day 21 along with CML produced significant (P < 0.01) lowering of serum AST, ALT, ALP, gamma-GTP and tissue lipid peroxide levels. The results were comparable to silymarin (25 mg/kg, orally). The study shows that the reduction of liver damage by ethanol ginger extract treatment involves several mechanisms.
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