期刊
IMMUNITY
卷 18, 期 2, 页码 243-253出版社
CELL PRESS
DOI: 10.1016/S1074-7613(03)00024-4
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资金
- Telethon [GP0117Y01] Funding Source: Medline
Upon encounter with antigen, B lymphocytes differentiate into Ig-secreting plasma cells. This step involves a massive development of secretory organelles, most notably the endoplasmic reticulum. To analyze the relationship between organelle reshaping and Ig secretion, we performed a dynamic proteomics study of B lymphoma cells undergoing in vitro terminal differentiation. By clustering proteins according to temporal expression patterns, it appeared that B cells anticipate their secretory role in a multistep process. Metabolic capacity and secretory machinery expand first to accommodate the mass production of IgM that follows.
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