期刊
TRENDS IN PARASITOLOGY
卷 19, 期 2, 页码 88-93出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4922(02)00053-3
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- NIAID NIH HHS [AI44375, AI47840] Funding Source: Medline
T cells from different subsets play a major role in protective immunity against pre-erythrocytic stages of malaria parasites. Exposure of humans and animals to malaria sporozoites induces (alphabeta CD8(+) and CD4(+) T cells specific for antigens expressed in pre-erythrocytic stages of Plasmodium. These T cells inhibit parasite development in the liver, and immunization with subunit vaccines expressing the respective antigenic moieties confers protection against sporozoite challenge. gammadelta and natural killer T cells can also play a role in protective immunity. Recent studies with mice transgenic for the alphabeta T-cell receptor have revealed the existence of complex mechanisms regulating the induction and development of these responses.
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