期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 4, 期 2, 页码 95-104出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1019
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A newly discovered family of cytoplasmic proteins-the NALPs-has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.
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