期刊
ANNALS OF NEUROLOGY
卷 53, 期 2, 页码 259-263出版社
WILEY-LISS
DOI: 10.1002/ana.10467
关键词
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资金
- NHLBI NIH HHS [R01HL 64766] Funding Source: Medline
- NINDS NIH HHS [P01 NS23393, R01 NS33627, R01NS38292] Funding Source: Medline
We intracisternally transplanted subventricular zone (SVZ) cells labeled by ferromagnetic particles into stroked rats. Migration of transplanted cells was noninvasively tracked using magnetic resonance imaging (MRI). We found that transplanted cells selectively migrated towards the ischemic parenchyma at a mean speed of 65 +/- 14.6 mum/hr in living rats. Migration of transplanted cells in the brain was also measured histopathologically. Rats transplanted with SVZ cells exhibited significant improvement of neurological function. Our data suggest that intracisternal transplantation of SVZ cells provides an avenue for cell therapy of stroke and that MRI can be used to track grafted cells in the brain.
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