期刊
NATURE REVIEWS IMMUNOLOGY
卷 3, 期 2, 页码 123-132出版社
NATURE PORTFOLIO
DOI: 10.1038/nri1000
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Although they were used initially as non-specific immunosuppressants in transplantation, CD3-specific monoclonal antibodies have elicited renewed interest owing to their capacity to induce immune tolerance. In mouse models of autoimmune diabetes, CD3-specific antibodies induce stable disease remission by restoring tolerance to pancreatic P-cells. This phenomenon was extended recently to the clinic - preservation of beta-cell function in recently diagnosed patients with diabetes was achieved by short-term administration of a CD3-specific antibody. CD3-specific antibodies arrest ongoing disease by rapidly clearing pathogenic T cells from the target. Subsequently, they promote long-term T-cell-mediated active tolerance. Recent data indicate that transforming growth factor-beta-dependent CD4(+)CD25(+) regulatory T cells might have a central role in this effect.
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