期刊
LANCET
卷 361, 期 9355, 页码 393-395出版社
LANCET LTD
DOI: 10.1016/S0140-6736(03)12384-7
关键词
-
资金
- NCI NIH HHS [R29CA69421] Funding Source: Medline
- NIA NIH HHS [AG13478, K01 AG00767] Funding Source: Medline
During normal ageing, the gradual loss of telomeric DNA in dividing somatic cells can contribute to replicative senescence, apoptosis, or neoplastic transformation. In the genetic disorder dyskeratosis congenita, telomere shortening Is accelerated, and patients have premature onset of many age-related diseases and early death. We aimed to assess an association between telomere length and mortality In 143 normal unrelated individuals over the age of 60 years. Those with shorter telomeres in blood DNA had poorer survival, attributable In part to a 3.18-fold higher mortality rate from heart disease (95% CI 1.36-7.45, p=0.0079), and an 8.54-fold higher mortality rate from infectious disease (1.52-47.9, p=0.015). These results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据