期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 197, 期 3, 页码 315-322出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20021829
关键词
antibody; transport; half-life; pharmacokinetics; metabolism
资金
- NCI NIH HHS [CA88053, R01 CA088053] Funding Source: Medline
- NICHD NIH HHS [HD38764, R01 HD038764] Funding Source: Medline
- NIDDK NIH HHS [R01 DK056597, DK56597] Funding Source: Medline
The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a. catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histo compatibility complex-related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.
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