期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 100, 期 3, 页码 1358-1363出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0337681100
关键词
dopaminergic amacrines; interplexiform cells; AII amacrines; GABA(A) receptors
资金
- NEI NIH HHS [R01 EY001344, EY-01344] Funding Source: Medline
In the retina, dopaminergic amacrine (interplexiform) cells establish multiple synapses on the perikarya of All amacrines, the neurons that distribute rod signals to on-and off-cone bipolars. We used triple-label immunocytochemistry and confocal microscopy to identify the receptors contained within the postsynaptic active zone of these synapses in both mouse and rat retinas. We found that at the interface between the dendrites of the dopaminergic neurons and the All amacrine cell perikarya clusters of postsynaptic,gamma-aminobutyric acid type A (GABAA) receptors are situated in register with aggregates of presynaptic organelles immunoreactive for GABA, the GABA vesicular transporter, and the vesicular monoamine transporter-2. D1 and D2/3 dopamine receptors, on the other hand,do not form clusters on the surface of the perikarya of All amacrine cells. We suggest that the synapses between retinal dopaminergic neurons and All amacrine cells are GABAergic and that both GABA and dopamine are released by the presynaptic endings. GABA acts on the ionotropic receptors clustered at the postsynaptic active zone, whereas dopamine diffuses to more distant, slower-acting metabotropic receptors.
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