期刊
NEURON
卷 37, 期 3, 页码 463-472出版社
CELL PRESS
DOI: 10.1016/S0896-6273(02)01189-3
关键词
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资金
- NINDS NIH HHS [NS36999] Funding Source: Medline
Information processing in the neuron requires spatial summation of synaptic inputs at the dendrite. In CA1 pyramidal neurons of the hippocampus, a brief period of correlated pre- and postsynaptic activity, which induces long-term potentiation (LTP) or long-term depression (LTD), results in a persistent increase or decrease in the linearity of spatial summation, respectively. Such bidirectional modification of the summation property is specific to the modified input and reflects localized dendritic changes involving I-h channels and NMDA receptors. Thus, correlated pre- and postsynaptic activity alters not only the strength of the activated input but also its dendritic integration with other inputs.
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