Condensed aromatic peptide family of microbial Metabolites, inhibitors of CD28-CD80 interactions

Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28-CD80 binding with an IC50 of 0.42, 0.38 and 0.22 muM, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.